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have systematically addressed the functional characterization of the positive regulatory and distinct core regions of GPX4 promoters in mouse various tissues and cells by site-directed mutagenesis and electrophoretic mobility shift analysis (EMSA), successively [44,45]

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Inflammatory mediators can induce production of prostaglandin E 2 (PGE 2 ) and NO, which in turn have the capacity to promote maturation and increase transport of melanosomes, to upregulate the expression of the tyrosinase gene, and to increase the complexity of the network of melanocytic dendrites

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