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Similarly, for dual/triple agonists, regulatory agencies will demand evidence of incremental benefit vs risk over existing agents
Based on clinical trial data, retatrutide produces greater average weight loss (28.7% at 68 weeks with 12mg) compared to tirzepatide (22.5% at 72 weeks with 15mg)
10.1186/s12916-025-04018-w BMC Med
The primary factor is the loss of appetite suppression
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