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Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder globally, surpassed only by Alzheimers disease (Zaguirre, 2023)

It increases VEGF receptor activity to promote new blood vessel formation, enhances collagen synthesis and organization, activates the ERK1/2 signaling pathway for cell proliferation and migration, and modulates inflammatory responses to optimize healing conditions

Finally, we validated that the peptide inhibitor exhibited robust selectivity for senescent cells and efficiently disrupted FOXO4-p53 foci formation despite its short length and L-type amino acid composition