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lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy
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Clinical trial results for GLP-1 medications have been genuinely impressive
However, there have been inconsistent findings using proton magnetic resonance spectroscopy ( 1 H-MRS) to directly measure regional levels of these neurotransmitters (see Brennan et al
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