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Which HRT delivery methods are affected Affected by GLP-1 medications (oral delivery): Oral estrogen tablets (conjugated equine estrogens, estradiol) Oral progesterone (micronized progesterone, such as Utrogestan) Oral progestins (norethisterone, medroxyprogesterone) Oral testosterone (testosterone undecanoate) NOT affected by GLP-1 medications (non-oral delivery): Transdermal estrogen patches Topical estrogen gels and creams Vaginal estrogen rings or suppositories Progesterone-releasing IUD (Mirena) Transvaginal progesterone Testosterone injections Testosterone pellets Testosterone patches or gels The distinction is simple
These medications, such as liraglutide and semaglutide, have shown significant results, demonstrating not only improved glycemic control but also substantial weight loss in patients
10.1056/NEJMoa1509225 77 PsichasA.SleethM
Lau et al., 2010
Vascular Pharmacology, 106, 54-66
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