surmount-1 trial tirzepatide non-diabetic weight loss after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 Clinical trials of subcutaneous tirzepatide

While not primarily a fat loss compound, these effects support body recomposition when combined with appropriate training and nutrition

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Sagvolden T, Johansen EB, Woien G, Walaas SI, Storm-Mathisen J, Bergersen LH, et al

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Gastrointestinal side effects are the primary reason people discontinue tirzepatide, and moving through doses too quickly dramatically increases that risk