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Weight loss generally begins within the first month but follows a gradual trajectory, with continued loss typically occurring for 9-12 months before plateauing

In PIONEER 18, the baseline HbA 1c ranged from 64.067.3 mmol/mol (8.08.3%), and the baseline body weight from 85.994.0 kg, compared with 78.0 mmol/mol (9.28%) and 109.7 kg in the oral semaglutide arm of our study [9]

The mechanism is mechanistically additive: GHRH directly stimulates somatotrophs through a separate receptor, while GHRPs suppress somatostatin and prime GHSR-1a simultaneously

Int J Sport Nutr Exerc.Metab 2000;10(2):199-207