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While demand for GLP-1 drugs appears to be accelerating, uncertainty around affordability, insurance coverage, and long-term access continues to shape whether interest translates into actual treatment

According to Gigliotti, [Weight management medications] can make eating healthier easier because people may experience fewer cravings and less temptation to overeat. Share that stopping weight management drugs can result in weight regain

Common and physiologically insignificant, but preventable with technique adjustment

by simultaneously enhancing antioxidant capacity, inhibiting ROS-generating pathways, and improving mitochondrial resilience (175177), exerkines may overcome the inherent limitations of single-agent antioxidant strategies and offer a more durable therapeutic approach for DR

For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank