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Alongside GLP-1 is GIP (glucose-dependent insulinotropic peptide), made by K-cells higher up the intestine

On the other hand, a triplet combination that added garetosmab showed even better results - preserving more muscle and burning more fat

But there are more serious side effects that include: Kidney problems, severe allergic reactions, and an increased risk of skin cancer, especially in people with pre-existing skin conditions (there have been reports of Melanoma diagnosis within four weeks of using Melanotan)

Discussion To the best of our knowledge, this is a latest systematic review and meta-analysis to examine the current evidence of ALC use in mood disorders especially MDD across RCTs and non-randomized trials as well