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That said, the polarity of NOs effects may be reversible in some pathological contexts, including under conditions of hypoxia (Zanelli et al., 2002)

In 32% of all study patients, severe skin irritation led to temporary discontinuation of topical tretinoin 0.02% (about 7%), or led to use of a mild topical corticosteroid

Treatment typically begins at a low dose (2.5 mg weekly) with gradual titration to minimize side effects

In preclinical research models, exposure to GHK-Cu has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover