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In the biomarker discovery and validation set, the disease group consisted of a mixture of patients exposed and unexposed to drug treatment including antidepressants for the treatment of MDD

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First, the T2D population lost less weight than the general-obesity population in TRIUMPH-1 (-20.8% vs -28.3% at 12 mg) -- expected for this drug class, and the reason the two trials are reported separately

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Both options are effective, but they work in slightly different ways