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In addition, oral VK2735 demonstrated encouraging safety and tolerability following 28 days of once-daily dosing, and no serious adverse events (SAEs) have been reported to date

After release of TML by lysosomal protein degradation, this compound is hydroxylated by TMLD, after which the resulting HTML is cleaved by a specific aldolase, which uses pyridoxal 5-phosphate (PLP) as a cofactor, into TMABA and glycine Substrate and Intermediate Compounds Trimethyllysine (TML) TML is the starting substrate for carnitine biosynthesis, derived from the methylation of lysine residues in proteins

Avoid frequent temperature cycling by minimizing door-open time