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We begin with the scientific background tracing the incretin concept from early 20th-century experiments through the discovery of GLP-1 in the 1980s

doi: 10.1016/j.tcm.2021.12.008

Safety and Monitoring - Always start with a low dose to assess tolerance

If the body is weakened, the viruses can repeatedly migrate to the surface of the skin and cause the typical herpes symptoms

That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant