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Indications and Usage for B-12 Compliance Injection Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see DRUG INTERACTION), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
In biochemical and dermal research models, it is utilized to study extracellular matrix remodeling and vascular endothelial growth factor (VEGF) expression
In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)
Stage 4: Macrocytic anemia (abnormally large red blood cells) seen on laboratory testing
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