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Type 2 diabetes is a complex disease and the significant glucose control and weight loss achieved with once-weekly semaglutide compared with dulaglutide are encouraging, as more treatment options are needed. Safety Safety profiles were similar between patients given semaglutide and dulaglutide, and less than 10% of patients had to discontinue therapy prematurely due to adverse events across all treatment groups

These issues underscore the importance of understanding where GLP1 medications come from and why FDA approval plays a critical role in protecting patient safety

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That same body of work also shows meaningful weight outcomes: in one study of 500 patients, 75% reported significant weight loss with semaglutide, and these changes drive downstream shifts in lipids and cardiovascular markers

Prescription of guideline-directed medical therapies in patients with diabetes and chronic kidney disease from the CURE-CKD Registry, 2019-2020