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One question we're frequently asked is how safe semaglutide is, not just for short-term use, but for long-term use

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[6] [16] Healthcare professionals should also monitor for adverse effects and assess the impact on weight-related comorbidities such as type 2 diabetes, hypertension, and obstructive sleep apnoea

Central GLP-1R activation in hypothalamic and mesolimbic pathways may lead to fatigue, lethargy, or brain fog 63 , though such effects might be often transient and dose-dependent