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Pregnant, breastfeeding, anyone with personal or family history of thyroid cancer, history of gallbladder disease or pancreatitis, or MENs2

4 In catabolic circumstances, the levels of IGF-1 decrease while its binding proteins increase, leading to a lower local IGF-1 activity and contributing to the decreased insulin sensitivity seen in catabolism

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Most researchers prefer ipamorelin for body composition protocols because its selective GH release avoids the cortisol elevation GHRP-2 produces