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For dermal melasma (as diagnosed by a clinician using a dermatoscope), I am normally involved in management (as if my nurses, physicians, dermal therapists are involved, I usually end up seeing these patients)
Weight loss might be slow at first, and thats okay
It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate
Research goal Investigate GLP-1 receptor signaling involved in metabolic regulation, insulin activity, and appetite pathways
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