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Weight loss procedures such as calorie restriction and metabolic/bariatric surgery are known to affect bone health because they elevate bone turnover markers (BTMs) and reduce bone mineral density (BMD) [7,8,9]
Clinical trials show that semaglutide added to metformin produces substantial weight loss, with studies demonstrating reductions averaging 56 kg over 56 weeks at diabetes doses (1.0 mg weekly)
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