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These symptoms typically emerge during dose escalation and often diminish over 4-8 weeks as tolerance develops
By 12 weeks , average weight loss ranges from 35% of initial body weight, with this figure increasing to 1015% or more by 612 months in responders, particularly with higher-dose formulations like semaglutide 2.4 mg (Wegovy)
Beginning an 18-month treatment course without a clear post-2027 plan means initiating that monitoring without knowing whether it will continue
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