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A fixed-effects model was used when the heterogeneity was considered to be significant (, when represented the sum of identical heterogeneity across all studies and represented the sum of sampling error across all studies ( Quality of evidence We evaluated the quality and strength of the evidence for each outcome based on the Graded Recommendations Assessment, Development and Evaluation (GRADE) method

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McAllister, M

At position 3 on the chain Glu(E) was substituted with Arg(R), which gives the name LR3