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Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, et al

Ion transport mechanisms, including the plasma membrane Ca 2+ ATPase (PMCA) and anion exchanger 1 (AE1, Band 3), also function as checkpoints: PMCA extrudes excess Ca 2+ to limit overload, with its activity modulated by ceramide or AA, while AE1 mutations disrupting ion balance promote eryptosis (Nicolay et al., 2008

And on the flip-side, too-high levels have been detected in patients with mania [14]

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The researchers reported improvement in more than 80% of the patients, but there was no control group