Crystal structures of the N-terminal extracellular domain of GLP-1R (nGLP-1R) show that the endogenous agonist, GLP-1, and the synthetic antagonist, exendin-4 [9-39] , bind to the extracellular domain via interactions primarily between conserved side chains in the FxxWL motif of GLP-1R peptide ligands and Trp39 of nGLP-1R [9], [10]
N Engl J Med 377:644657 Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes
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Both must adhere to the same standard of care and be compliant with state and federal laws
As clinical use of GLP-1 receptor agonists continues to expand, understanding how these medications alter the subjective/interoceptive effects of alcohol will be critical for optimizing their utility in AUD
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