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doi: 10.1016/j.bbadis.2024.167060 199 WangHLiuCZhaoYGaoG
At low concentrations (0.01 nM), MMP1 and MMP2 gene expression increases, facilitating removal of damaged extracellular matrix proteins
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7,8,13 Gut-derived peptides and bone There is now unmistakable evidence to demonstrate that gut hormones play a key role in regulating bone metabolism, particularly through inhibition of bone resorption
Increased FOXO4 expression correlates with enhanced proteasomal activity, leading to a reduction in the accumulation of damaged proteins, particularly in cardiovascular tissue
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