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Dose escalation strategy significantly impacts both efficacy and tolerability

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In smaller acute metabolic studies with DPP-4 inhibitors, a reduction of the post-prandial rise in triglycerides, and apolipoprotein-B 48 was observed

A landmark New England Journal of Medicine study found that individuals who believed they had slow metabolisms underreported calories by 47%, even though their hormone levels and metabolic function were normal