Also, a recent systematic review indicates that tirzepatide treatment in adults is associated with reductions in fat mass, relative preservation of lean mass, and decreases in MFI [69], all of which are critical for sarcopenia risk and functional capacity
A 4% drop in absolute LBM accompanying a 12% drop in body weight gives roughly 20% of weight loss as 'lean tissue.' Batsis reports closer to 35% and as Langer makes clear later in this piece, the gap between those numbers is partly explained by what DXA actually counts as 'lean
10.1038/s41366-021-01000-z 37 LeeN
Research backs this up: when using GLP-1s to aid in weight loss, they were found to effectively reduce BMI, triglycerides, waist circumference, and total testosterone in people with PCOS, according to a 2024 meta-analysis in the Journal of Diabetes and its Complications
That feels misleading