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B12 supports normal energy production and pairs well with nutrition coaching and exercise
Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted
But remember, B12 shots and weight loss work best when combined with the right diet and regular exercise
Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)
Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
