Results from these clinical trials were promising, showing that the combination therapy was well-tolerated and effective
Disulfide- and diselenide-linked carriers enable GSH-responsive controlled release but may have stability issues
They are not intended to represent clinical evidence in humans, and PT-141 has not been approved by the FDA, EMA, or any other regulatory authority for any indication
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doi: 10.3389/fonc.2026.1751474 Received 21 November 2025 Revised 14 January 2026 Accepted 03 February 2026 Published 18 February 2026 Volume 16 - 2026 Edited by Dana Kristjansson, Norwegian Institute of Public Health (NIPH), Norway Reviewed by Feng Wang, Affiliated Hospital of Nantong University, China Bingran Yu, Shandong University, China Updates Copyright 2026 Pathania and Osna