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To identify small molecules that enhance this pathway, we screened 5,170 FDA-approved and natural compounds using HEK293 cells with a TCF/LEF luciferase reporter

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doi: 10.1016/j.ejps.2025.107046 217 KianderWSinokkiANeuvonenMKidronHNiemiM

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In cognitive studies on elderly mice (28 months old), GHK-Cu administered at 10 mg/kg five times per week for three weeks produced significantly faster maze navigation, suggesting partial reversal of age-related cognitive decline