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This work was supported by Shandong medical and health science and technology development plan project (Grant number 202003030357), Postdoctoral Science Foundation of China (RZ2100002858), the Qingdao Natural Science Foundation (24-4-4-zrjj-115-jch) and Qingdao Medical and Health Science and Technology Development Plan Project (2023-WJZD069) to Hongyun Wei

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