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Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)

2020;30:341123.e7

These biomarkers of cellular aging correlated with the observed cognitive improvements, suggesting Epithalon's cognitive benefits may stem from systemic cellular rejuvenation rather than isolated neural effects

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As a fragment of naturally occurring thymosin beta-4, the peptide aligns with endogenous human biology