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[1] [2] The FDA has approved these agents specifically for type 2 diabetes management and, in some formulations, for weight management in adults with obesity or overweight with at least one weight-related comorbidity

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Our data demonstrate that the adaptive metabolic response to 5FU is mediated through the inhibition of TS function, as we recapitulate these phenotypes by genetic silencing or targeted inhibition of TS using antifolates

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