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A study with bipolar patients and schizophrenia subjects also observed no robust differences between patients and controls either for allele frequencies or genotype distribution of C677T polymorphism 66

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Particularly, they found a positive relation between serum D-lactate (a marker of increased intestinal permeability) and markers of hepatocytes necrosis, cholestasis, and triglycerides metabolism [47]

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Associations between increases in GGT and the metabolic syndrome both fatal and non-fatal coronary heart disease (CHD) events, atherosclerosis and fatty liver, gestational diabetes,cancer, hypertension, and carotid intima-media thickness have been documented in large and well-conducted studies