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The acid disrupts the copper-peptide bond, releasing free copper while deactivating the GHK tripeptide

doi: 10.1186/s12951-025-03258-5 150 LinYJinJHanQHangDChenZYeSet al

This work was funded by the METROFOOD-CZ Research Infrastructure Project (MEYS grant number: LM2018100 and LM2023064) and internal grant of the UCT Prague No

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KYN levels were elevated (~ 2.1-fold), and TDO expression (both glial density and intensity in grey and white matter) was significantly higher, suggesting that enhanced KP metabolism may contribute to psychotic features in bipolar disorder