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The once-effortless balance between calories in and calories out is suddenly disrupted: weight gain gathers around the abdomen, cholesterol climbs, insulin sensitivity declines, and hot flashes arrive as an unwelcome guest

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Finally, mutant p53 GOF activities, including the facilitation of cell proliferation, invasion, survival, cancer-promoting metabolism, protumorigenic inflammation, and drug resistance, have been observed in a series of experimental models, and multiple GOF mechanisms have been proposed