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Potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in substance use disorder: a systematic review of randomized trials
4 Central GLP-1R pathways linking metabolic regulation and addiction circuits GLP-1 Rs are broadly distributed in brain circuits that play pivotal roles in motivation, including the striatum, hypothalamus, ventral tegmental area (VTA), and extended limbic regions such as the central amygdala and the infralimbic/prelimbic cortex (Pyke et al., 2014
Routine liver function monitoring is not specifically required for tirzepatide according to FDA prescribing information
Winter months in provinces like Alberta, Manitoba, Saskatchewan, and Ontario can make outdoor walking impractical for weeks at a time
treatment difference 10.2%
