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2 Methods 2.1 3D modeling of colistin and daptomycin The structures of colistin and daptomycin were obtained from the Protein Data Bank (PDB) with PDB ID reference 5L3G (Speranzini et al., 2016) and 1XT7 (Ho et al., 2008) respectively and then validated with the software MolProbity ( accessed on 20 January 2023) and PROSA ( accessed on 21 January 2023)

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