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We observed increased incorporation of [ 13 C]glutamine carbons into multiple metabolites, including the TCA cycle intermediates alphaketoglutarate and malate, as well as pyruvate, in tumors relative to adjacent nontumor tissues (Fig EV3C)

Overdose depletes glutathione entirely, but even therapeutic doses can increase glutathione turnover and sometimes lower antioxidant capacity

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Kennedy Jr., Secretary of the Department of Health and Human Services (HHS), proposed removing these restrictions