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The equivalent arginine-serine network in Rattus norvegicus OAT1 has been implicated in gating dynamics and the allosteric modulation of OAT1 by chloride 25 , with chloride binding to R466 rOAT1 in the inward-facing conformation stabilising this network

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The rare but real risk of probiotic bacteremia makes this population unsuitable for any live probiotic supplementation without physician oversight