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Research shows semaglutide can reduce alcohol consumption by up to 40% in individuals with obesity, significantly outperforming traditional FDA-approved medications like naltrexone, which only reduce relapse rates by 5%

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Structures of the GLP-1R in complex with G s , bound with GLP-1 and exendin-P5, as well as non-peptide ligands, have been determined using cryo-EM 13,16,27

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