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Tirzepatide has a long half-life of about five days, which means even once-weekly dosing produces relatively stable plasma concentrations at steady state

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Lilly's first Phase 3 readout (TRIUMPH4) reported strong results in people with obesity/overweight and knee osteoarthritis, including: ~28.7% average weight loss at 68 weeks at the 12 mg dose (topline reporting), plus improvements in pain and function measures The important phrase there is "topline"