Mechanistically, SLC25A39 deficiency induced mitochondrial dysfunction, characterized by excessive mitochondrial reactive oxygen species (ROS), reduced membrane potential, diminished adenosine triphosphate (ATP) synthesis, aberrant mitochondrial permeability transition pore (mPTP) opening, and cytochrome c release
Since menopause itself can cause similar symptoms, finding the right combination requires patience and careful monitoring
The study protocol was approved by the Research Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (registration code: IR.AJUMS.REC.1401.416) and all the participants completed the written consent form
Like most things in nutrition and healthcare, its nuanced and my perspective has evolved as these medications have become more widely used
Diet and exercise Participants were encouraged to maintain their normal dietary intake during an initial baseline week