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Chovatiya R, Medzhitov R

The presence of obesity-related complications such as obstructive sleep apnea, metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), or cardiovascular disease may justify longer treatment duration given the health benefits of sustained weight loss

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We have other tools in the toolbox for treating obesity if someone hasn't achieved weight loss with a GLP-1

Rare but serious risks of Zepbound and Ozempic Both medications come with similar warnings and potential health complications, though these are rare