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In the SELECT CV outcome trial, which included patients aged 45 years or older with a body mass index (BMI) 27.0 kg m 2 and established ASCVD but without diabetes, those treated with the glucagon-like peptide-1 receptor agonist (GLP-1RA), semaglutide 2.4 mg, had a 20% MACE reduction compared with those receiving placebo on top of standard of care 12

However, given the fundamental role of energy metabolism in biological processes and current research evidence, investigations focusing on lactate and histone lactylation modifications represent promising research directions for developing therapeutic strategies against metabolic diseases, particularly malignancies