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While liver biopsy remains the gold standard for fibrosis evaluation, its invasiveness and associated risks make it less suitable for routine clinical application [52]

In contrast, suppression of ACL, which potentially reduces citrate-derived acetyl-CoA, does not inhibit GSIS [60]

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Mutations in SOD1 can cause familial ALS (several pieces of evidence also show that wild-type SOD1, under conditions of cellular stress, is implicated in a significant fraction of sporadic ALS cases, which represent 90% of ALS patients.), [58] by a mechanism that is presently not understood, but not due to loss of enzymatic activity or a decrease in the conformational stability of the SOD1 protein

The mechanisms by which peptides exert their therapeutic effects are diverse, ranging from hormone replacement and receptor modulation to enzyme inhibition, direct cellular interactions, and tissue repair processes