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If you have chronic kidney disease, liver disease, or are taking medications that affect kidney or liver function, your provider may need to adjust the pyridoxine dose in your compound or monitor B6 levels more frequently

However, significant weight loss may reduce thyroid hormone requirements, potentially necessitating levothyroxine dose adjustments as patients lose weight

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27% of patients achieved more than 15% weight loss compared to 0% on placebo

All you need to do is follow their instruction