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Note: This can be tricky to time around pre- and post-workout nutrition

Fatigue Fatigue is often reported during the initial adjustment period and is usually related to changes in caloric intake and blood sugar regulation rather than the medication itself

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While the changes in lipid parameters are smaller compared to those elicited by LY2405319 or PF-05231023, pegbelfermin is the first FGF21 analog to demonstrate beneficial hepatic effects in NASH patients, with daily administration yielding approximately a 30% relative reduction in liver fat content

GLP-1 receptor activation inhibits the activation of hepatic Kupffer cells and infiltrating macrophages, leading to decreased production of pro-inflammatory cytokines such as TNF- and IL-1, thereby attenuating hepatic inflammation (44)