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Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors
However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain
This depends on their health and how they react to the treatment
MOTS-c has also garnered attention for possible benefits related to aging
As with any treatment, periodic evaluation ensures continued safety
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