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Some patients have reported skin sensitivity at the treatment site, but this has been fairly mild and not required pain medications

It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]

Case report Acta Gastroenterol Belg

It also offers anti-inflammatory, gut, and organ support