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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Clinical Pearl: Before parenteral B12, always think: Check potassium Prevent hypokalemic arrhythmia Medicine is often about anticipating the treatment complication before it happens
Treatment involves hydroxocobalamin injections for confirmed deficiency and lifestyle modification for fatty liver disease management
Drug Discovery Today, 28 (10), 103714
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